Neurite Collapse and Altered ER Ca(2+) Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

The Parkinson disease (PD) genetic LRRK2 gain-of-function mutations may relate to the ER pathological changes seen in PD patients at postmortem. Human induced pluripotent stem cell (iPSC)-derived neurons with the PD pathogenic LRRK2 G2019S mutation exhibited neurite collapse when challenged with the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Korecka, Joanna A., Talbot, Sebastien, Osborn, Teresia M., de Leeuw, Sherida M., Levy, Simon A., Ferrari, Eliza J., Moskites, Alyssa, Atkinson, Elise, Jodelka, Francine M., Hinrich, Anthony J., Hastings, Michelle L., Woolf, Clifford J., Hallett, Penelope J., Isacson, Ole
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335600/
https://ncbi.nlm.nih.gov/pubmed/30595548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.11.021
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados