An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma

Glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) plays a critical role in cancer metabolism by coordinating glycolysis and biosynthesis. A well-validated PGAM1 inhibitor, however, has not been reported for treating pancreatic ductal adenocarcinoma (PDAC), which is one of the deadliest malignancie...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wen, Chen-Lei, Huang, Ke, Jiang, Lu-Lu, Lu, Xiong-Xiong, Dai, Yu-Ting, Shi, Min-Min, Tang, Xiao-Mei, Wang, Qing-Bing, Zhang, Xiao-Dan, Wang, Peng-Hui, Li, Hui-Ti, Ruan, Xiao-Xue, Wang, Li-Wen, Wang, Xin-Jing, Wang, Qian, Lu, Wei, Xiang, Xiao-Qiang, Sun, Xun, Xu, Yan-Hui, Lai, Lu-Hua, Zhan, Qian, Li, Hong-Wei, Peng, Cheng-Hong, Chen, Jing, Huang, Jin-Yan, Ye, De-Yong, Chen, Sai-Juan, Chen, Zhu, Li, Min, Fang, Yuan, Shen, Bai-Yong, Zhou, Lu
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859357/
https://ncbi.nlm.nih.gov/pubmed/31662475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914557116
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