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Quantifying the impact of treatment history on plasmid-mediated resistance evolution in human gut microbiota

To understand how antibiotic use affects the risk of a resistant infection, we present a computational model of the population dynamics of gut microbiota including antibiotic resistance-conferring plasmids. We then describe how this model is parameterized based on published microbiota data. Finally,...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Tepekule, Burcu, Abel zur Wiesch, Pia, Kouyos, Roger D., Bonhoeffer, Sebastian
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859334/
https://ncbi.nlm.nih.gov/pubmed/31666328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912188116
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