Genomic landscape of metastatic breast cancer and its clinical implications

Whole genome sequencing (WGS) of prospectively collected tissue biopsies of 442 metastatic breast cancer (mBC) patients reveals that, compared to primary BC, tumour mutational burden (TMB) doubled, relative contributions of mutational signatures shifted, and mutation frequency of six known driver ge...

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書誌詳細
出版年:Nat Genet
主要な著者: Angus, Lindsay, Smid, Marcel, Wilting, Saskia M., van Riet, Job, van Hoeck, Arne, Nguyen, Luan, Nik-Zainal, Serena, Steenbruggen, Tessa G., Tjan-Heijnen, Vivianne C.G., Labots, Mariette, van Riel, Johanna M.G.H., Bloemendal, Haiko J., Steeghs, Neeltje, Lolkema, Martijn P., Voest, Emile E., van de Werken, Harmen J.G., Jager, Agnes, Cuppen, Edwin, Sleijfer, Stefan, Martens, John W.M.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858873/
https://ncbi.nlm.nih.gov/pubmed/31570896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0507-7
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