Genomic landscape of metastatic breast cancer and its clinical implications

Whole genome sequencing (WGS) of prospectively collected tissue biopsies of 442 metastatic breast cancer (mBC) patients reveals that, compared to primary BC, tumour mutational burden (TMB) doubled, relative contributions of mutational signatures shifted, and mutation frequency of six known driver ge...

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Detaylı Bibliyografya
Yayımlandı:Nat Genet
Asıl Yazarlar: Angus, Lindsay, Smid, Marcel, Wilting, Saskia M., van Riet, Job, van Hoeck, Arne, Nguyen, Luan, Nik-Zainal, Serena, Steenbruggen, Tessa G., Tjan-Heijnen, Vivianne C.G., Labots, Mariette, van Riel, Johanna M.G.H., Bloemendal, Haiko J., Steeghs, Neeltje, Lolkema, Martijn P., Voest, Emile E., van de Werken, Harmen J.G., Jager, Agnes, Cuppen, Edwin, Sleijfer, Stefan, Martens, John W.M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858873/
https://ncbi.nlm.nih.gov/pubmed/31570896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0507-7
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