Genomic landscape of metastatic breast cancer and its clinical implications

Whole genome sequencing (WGS) of prospectively collected tissue biopsies of 442 metastatic breast cancer (mBC) patients reveals that, compared to primary BC, tumour mutational burden (TMB) doubled, relative contributions of mutational signatures shifted, and mutation frequency of six known driver ge...

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Bibliografiset tiedot
Julkaisussa:Nat Genet
Päätekijät: Angus, Lindsay, Smid, Marcel, Wilting, Saskia M., van Riet, Job, van Hoeck, Arne, Nguyen, Luan, Nik-Zainal, Serena, Steenbruggen, Tessa G., Tjan-Heijnen, Vivianne C.G., Labots, Mariette, van Riel, Johanna M.G.H., Bloemendal, Haiko J., Steeghs, Neeltje, Lolkema, Martijn P., Voest, Emile E., van de Werken, Harmen J.G., Jager, Agnes, Cuppen, Edwin, Sleijfer, Stefan, Martens, John W.M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858873/
https://ncbi.nlm.nih.gov/pubmed/31570896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0507-7
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