Genomic landscape of metastatic breast cancer and its clinical implications

Whole genome sequencing (WGS) of prospectively collected tissue biopsies of 442 metastatic breast cancer (mBC) patients reveals that, compared to primary BC, tumour mutational burden (TMB) doubled, relative contributions of mutational signatures shifted, and mutation frequency of six known driver ge...

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Publicado no:Nat Genet
Main Authors: Angus, Lindsay, Smid, Marcel, Wilting, Saskia M., van Riet, Job, van Hoeck, Arne, Nguyen, Luan, Nik-Zainal, Serena, Steenbruggen, Tessa G., Tjan-Heijnen, Vivianne C.G., Labots, Mariette, van Riel, Johanna M.G.H., Bloemendal, Haiko J., Steeghs, Neeltje, Lolkema, Martijn P., Voest, Emile E., van de Werken, Harmen J.G., Jager, Agnes, Cuppen, Edwin, Sleijfer, Stefan, Martens, John W.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858873/
https://ncbi.nlm.nih.gov/pubmed/31570896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0507-7
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