Mechanisms regulating PD-L1 expression on tumor and immune cells

BACKGROUND: The PD-1/PD-L1 checkpoint is a central mediator of immunosuppression in the tumor immune microenvironment (TME) and is primarily associated with IFN-g signaling. To characterize other factors regulating PD-L1 expression on tumor and/or immune cells, we investigated TME-resident cytokines...

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Détails bibliographiques
Publié dans:J Immunother Cancer
Auteurs principaux: Chen, Shuming, Crabill, George A., Pritchard, Theresa S., McMiller, Tracee L., Wei, Ping, Pardoll, Drew M., Pan, Fan, Topalian, Suzanne L.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858680/
https://ncbi.nlm.nih.gov/pubmed/31730010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0770-2
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