Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease

Venous thromboembolism (VTE) is a significant cause of mortality(1), yet its genetic determinants remain incompletely defined. We performed a discovery genome-wide association study in the Million Veteran Program and UK Biobank testing ~13 million DNA sequence variants for association with VTE (26,0...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Klarin, Derek, Busenkell, Emma, Judy, Renae, Lynch, Julie, Levin, Michael, Haessler, Jeffery, Aragam, Krishna, Chaffin, Mark, Haas, Mary, Lindström, Sara, Assimes, Themistocles L., Huang, Jie, Lee, Kyung Min, Shao, Qing, Huffman, Jennifer E., Kabrhel, Christopher, Huang, Yunfeng, Sun, Yan V., Vujkovic, Marijana, Saleheen, Danish, Miller, Donald R., Reaven, Peter, DuVall, Scott, Boden, William E., Pyarajan, Saiju, Reiner, Alex P., Trégouët, David-Alexandre, Henke, Peter, Kooperberg, Charles, Gaziano, J. Michael, Concato, John, Rader, Daniel J., Cho, Kelly, Chang, Kyong-Mi, Wilson, Peter W.F., Smith, Nicholas L., O’Donnell, Christopher J., Tsao, Philip S., Kathiresan, Sekar, Obi, Andrea, Damrauer, Scott M., Natarajan, Pradeep
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858581/
https://ncbi.nlm.nih.gov/pubmed/31676865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0519-3
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