HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype

Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine single nucleotide polymorphisms (SNPs) associated with the extent of abdominal (AAC, n = 9,417) or descending thoracic (TAC, n = 8,422) aortic...

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Foilsithe in:Nat Genet
Main Authors: Malhotra, Rajeev, Mauer, Andreas C., Cardenas, Christian L. Lino, Guo, Xiuqing, Yao, Jie, Zhang, Xiaoling, Wunderer, Florian, Smith, Albert V., Wong, Quenna, Pechlivanis, Sonali, Hwang, Shih-Jen, Wang, Judy, Lu, Lingyi, Nicholson, Christopher J., Shelton, Georgia, Buswell, Mary D., Barnes, Hanna J., Sigurslid, Haakon H., Slocum, Charles, O’Rourke, Caitlin, Rhee, David K., Bagchi, Aranya, Nigwekar, Sagar U., Buys, Emmanuel S., Campbell, Catherine Y., Harris, Tamara, Budoff, Matthew, Criqui, Michael H., Rotter, Jerome I., Johnson, Andrew D., Song, Ci, Franceschini, Nora, Debette, Stephanie, Hoffmann, Udo, Kälsch, Hagen, Nöthen, Markus M., Sigurdsson, Sigurdur, Freedman, Barry I., Bowden, Donald W., Jöckel, Karl-Heinz, Moebus, Susanne, Erbel, Raimund, Feitosa, Mary F., Gudnason, Vilmundur, Thanassoulis, George, Zapol, Warren M., Lindsay, Mark E., Bloch, Donald B., Post, Wendy S., O’Donnell, Christopher J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858575/
https://ncbi.nlm.nih.gov/pubmed/31659325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0514-8
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