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RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors

T cell specification and commitment requires Notch signaling. Although the requirement for Notch signaling during intrathymic T cell development is known, it is still unclear whether the onset of T cell priming can occur in a pre-thymic niche and whether RBPJ-dependent Notch signaling has a role dur...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Immunol
Prif Awduron: Chen, Edward L. Y., Thompson, Patrycja K., Zúñiga-Pflücker, Juan Carlos
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858571/
https://ncbi.nlm.nih.gov/pubmed/31636466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0518-7
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