Upregulation of IL-32 isoforms in virologically-suppressed HIV-infected individuals: Potential role in persistent inflammation and transcription from stable HIV-1 reservoirs

BACKGROUND: Human IL-32 is a polyfunctional cytokine that was initially reported to inhibit HIV-1 infection. However, recent data suggest that IL-32 may enhance HIV-1 replication by activating the HIV-1 primary targets, CD4+ T-cells. Indeed, IL-32 is expressed in multiple isoforms, some of which are...

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Publié dans:J Acquir Immune Defic Syndr
Auteurs principaux: Zaidan, Sarah M., Leyre, Louise, Bunet, Rémi, Larouche-Anctil, Etienne, Turcotte, Isabelle, Sylla, Mohamed, Chamberland, Annie, Chartrand-Lefebvre, Carl, Ancuta, Petronela, Routy, Jean-Pierre, Baril, Jean-Guy, Trottier, Benoit, MacPherson, Paul, Trottier, Sylvie, Harris, Marianne, Walmsley, Sharon, Conway, Brian, Wong, Alexander, Thomas, Réjean, Kaplan, Robert C., Landay, Alan L., Durand, Madeleine, Chomont, Nicolas, Tremblay, Cécile, El-Far, Mohamed
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6857723/
https://ncbi.nlm.nih.gov/pubmed/31714430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000002185
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