Association of TRPV1 and TLR4 through the TIR domain potentiates TRPV1 activity by blocking activation-induced desensitization

BACKGROUND: We have previously reported that histamine-induced pruritus was attenuated in toll-like receptor 4 (TLR4) knockout mice due to decreased transient receptor potential V1 (TRPV1) sensitivity. Our results implied that TLR4 potentiated TRPV1 activation in sensory neurons; however, the molecu...

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Publicado en:Mol Pain
Main Authors: Min, Hyunjung, Cho, Woo-Hyun, Lee, Hyunkyoung, Choi, Boomin, Kim, Yoon-Jung, Lee, Han Kyu, Joo, Yeonhee, Jung, Sung Jun, Choi, Se-Young, Lee, Soojin, Lee, Sung Joong
Formato: Artigo
Idioma:Inglês
Publicado: SAGE Publications 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856976/
https://ncbi.nlm.nih.gov/pubmed/30355052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806918812636
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