17β-Estradiol Attenuates Neuropathic Pain Caused by Spared Nerve Injury by Upregulating CIC-3 in the Dorsal Root Ganglion of Ovariectomized Rats

17β-estradiol plays a role in pain sensitivity, analgesic drug efficacy, and neuropathic pain prevalence, but the underlying mechanisms remain unclear. Here, we investigated whether voltage-gated chloride channel-3 (ClC-3) impacts the effects of 17β-estradiol (E2) on spared nerve injury (SNI)-induce...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Xu, Zhen-Zhen, Chen, Qin-Yi, Deng, Shi-Yu, Zhang, Meng, Tan, Chao-Yang, Yang Wang, Ma, Ke-Tao, Li, Li, Si, Jun-Qiang, Zhu, Li-Cang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856564/
https://ncbi.nlm.nih.gov/pubmed/31787875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.01205
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