Heterologous Expression of a Cryptic Gene Cluster from Streptomyces leeuwenhoekii C34(T) Yields a Novel Lasso Peptide, Leepeptin

Analysis of the genome sequence of Streptomyces leeuwenhoekii C34(T) identified biosynthetic gene clusters (BGCs) for three different lasso peptides (Lp1, Lp2, and Lp3) which were not known to be made by the strain. Lasso peptides represent relatively new members of the RiPP (ribosomally synthesized...

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Veröffentlicht in:Appl Environ Microbiol
Hauptverfasser: Gomez-Escribano, Juan Pablo, Castro, Jean Franco, Razmilic, Valeria, Jarmusch, Scott A., Saalbach, Gerhard, Ebel, Rainer, Jaspars, Marcel, Andrews, Barbara, Asenjo, Juan A., Bibb, Mervyn J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Genetics and Molecular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856326/
https://ncbi.nlm.nih.gov/pubmed/31562169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01752-19
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