Piezo1 channel activation mimics high glucose as a stimulator of insulin release

Glucose and hypotonicity induced cell swelling stimulate insulin release from pancreatic β-cells but the mechanisms are poorly understood. Recently, Piezo1 was identified as a mechanically-activated nonselective Ca(2+) permeable cationic channel in a range of mammalian cells. As cell swelling induce...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Deivasikamani, Vijayalakshmi, Dhayalan, Savitha, Abudushalamu, Yilizila, Mughal, Romana, Visnagri, Asjad, Cuthbertson, Kevin, Scragg, Jason L., Munsey, Tim S., Viswambharan, Hema, Muraki, Katsuhiko, Foster, Richard, Sivaprasadarao, Asipu, Kearney, Mark T., Beech, David J., Sukumar, Piruthivi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856185/
https://ncbi.nlm.nih.gov/pubmed/31727906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51518-w
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