Discovery of a potent small molecule inhibiting Huntington’s disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein

CAG repeats RNA causes various fatal neurodegenerative diseases exemplified by Huntington’s disease (HD) and several spinocerebellar ataxias (SCAs). Although there are differences in the pathogenic mechanisms, these diseases share the common cause, i.e., expansion of CAG repeats. The shared cause of...

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Vydáno v:Sci Rep
Hlavní autoři: Khan, Eshan, Mishra, Subodh Kumar, Mishra, Ribhav, Mishra, Amit, Kumar, Amit
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856162/
https://ncbi.nlm.nih.gov/pubmed/31728006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53410-z
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