Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons

Evolving concepts on Parkinson’s disease (PD) pathology suggest that α-synuclein (aSYN) promote dopaminergic neuron dysfunction and death through accumulating in the mitochondria. However, the consequence of mitochondrial aSYN localisation on mitochondrial structure and bioenergetic functions in neu...

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Pubblicato in:Cell Death Dis
Autori principali: Ganjam, Goutham K., Bolte, Kathrin, Matschke, Lina A., Neitemeier, Sandra, Dolga, Amalia M., Höllerhage, Matthias, Höglinger, Günter U., Adamczyk, Agata, Decher, Niels, Oertel, Wolfgang H., Culmsee, Carsten
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856124/
https://ncbi.nlm.nih.gov/pubmed/31727879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2091-2
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