Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells

Enhanced bone marrow adipogenesis and impaired osteoblastogenesis have been observed in obesity, suggesting that the metabolic microenvironment regulates bone marrow adipocyte and osteoblast progenitor differentiation fate. To determine the molecular mechanisms, we studied two immortalized murine ce...

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Pubblicato in:Bone Res
Autori principali: Tencerova, Michaela, Rendina-Ruedy, Elizabeth, Neess, Ditte, Færgeman, Nils, Figeac, Florence, Ali, Dalia, Danielsen, Morten, Haakonsson, Anders, Rosen, Clifford J., Kassem, Moustapha
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856123/
https://ncbi.nlm.nih.gov/pubmed/31754546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-019-0076-5
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