Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

Intracellular trafficking depends on the function of Rab GTPases, whose activation is regulated by guanine exchange factors (GEFs). The Rab5 GEF, Rabex5, was previously proposed to be auto-inhibited by its C-terminus. Here, we studied full-length Rabex5 and Rabaptin5 proteins as well as domain delet...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lauer, Janelle, Segeletz, Sandra, Cezanne, Alice, Guaitoli, Giambattista, Raimondi, Francesco, Gentzel, Marc, Alva, Vikram, Habeck, Michael, Kalaidzidis, Yannis, Ueffing, Marius, Lupas, Andrei N, Gloeckner, Christian Johannes, Zerial, Marino
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855807/
https://ncbi.nlm.nih.gov/pubmed/31718772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46302
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