N-Acetylcysteine Ameliorates Gentamicin-Induced Nephrotoxicity by Enhancing Autophagy and Reducing Oxidative Damage in Miniature Pigs

The clinical use of gentamicin over prolonged periods is limited because of dose and time-dependent nephrotoxicity, in which intracellular oxidative stress and heightened inflammation have been implicated. Macroautophagy/autophagy is an essential and highly conserved self-digestion pathway that play...

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Publicat a:Shock
Autors principals: Cui, Jing, Tang, Li, Hong, Quan, Lin, Shupeng, Sun, Xuefeng, Cai, Guangyan, Bai, Xue-Yuan, Chen, Xiangmei
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2019
Matèries:
Basic Science Aspects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855429/
https://ncbi.nlm.nih.gov/pubmed/30676497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000001319
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