The combination of metformin and 2‐deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease

BACKGROUND AND PURPOSE: The pathogenic mechanism of autosomal dominant polycystic kidney disease (ADPKD) is unclear. Similar to tumour cells, polycystic kidney cells are primarily dependent on aerobic glycolysis for ATP production. Compared with rodents, miniature pigs are more similar to humans. Th...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Lian, Xiaoying, Wu, Xiaoyuan, Li, Zhongxin, Zhang, Yingjie, Song, Kangkang, Cai, Guangyan, Li, Qinggang, Lin, Shupeng, Chen, Xiangmei, Bai, Xue‐Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365356/
https://ncbi.nlm.nih.gov/pubmed/30515768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14558
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