The combination of metformin and 2‐deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease

BACKGROUND AND PURPOSE: The pathogenic mechanism of autosomal dominant polycystic kidney disease (ADPKD) is unclear. Similar to tumour cells, polycystic kidney cells are primarily dependent on aerobic glycolysis for ATP production. Compared with rodents, miniature pigs are more similar to humans. Th...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Br J Pharmacol
Autores principales: Lian, Xiaoying, Wu, Xiaoyuan, Li, Zhongxin, Zhang, Yingjie, Song, Kangkang, Cai, Guangyan, Li, Qinggang, Lin, Shupeng, Chen, Xiangmei, Bai, Xue‐Yuan
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365356/
https://ncbi.nlm.nih.gov/pubmed/30515768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14558
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares