The combination of metformin and 2‐deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease

BACKGROUND AND PURPOSE: The pathogenic mechanism of autosomal dominant polycystic kidney disease (ADPKD) is unclear. Similar to tumour cells, polycystic kidney cells are primarily dependent on aerobic glycolysis for ATP production. Compared with rodents, miniature pigs are more similar to humans. Th...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Lian, Xiaoying, Wu, Xiaoyuan, Li, Zhongxin, Zhang, Yingjie, Song, Kangkang, Cai, Guangyan, Li, Qinggang, Lin, Shupeng, Chen, Xiangmei, Bai, Xue‐Yuan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365356/
https://ncbi.nlm.nih.gov/pubmed/30515768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14558
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