HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation

Reactivation of latent Human Cytomegalovirus (HCMV) in CD34(+) hematopoietic progenitor cells (HPCs) is closely linked to hematopoiesis. Viral latency requires maintenance of the progenitor cell quiescence, while reactivation initiates following mobilization of HPCs to the periphery and differentiat...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Mikell, Iliyana, Crawford, Lindsey B., Hancock, Meaghan H., Mitchell, Jennifer, Buehler, Jason, Goodrum, Felicia, Nelson, Jay A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6855405/
https://ncbi.nlm.nih.gov/pubmed/31725809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007854
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