P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine

BACKGROUND: Microglial activation contributes to the development of chronic migraine (CM). The P2Y12 receptor (P2Y12R), a metabolic purinoceptor that is expressed on microglia in the central nervous system (CNS), has been indicated to play a critical role in the pathogenesis of chronic pain. However...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Jing, Feng, Zhang, Yixin, Long, Ting, He, Wei, Qin, Guangcheng, Zhang, Dunke, Chen, Lixue, Zhou, Jiying
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854723/
https://ncbi.nlm.nih.gov/pubmed/31722730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1603-4
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