P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice

BACKGROUND: Central sensitization is an important pathophysiological mechanism of chronic migraine (CM). According to our previous studies, microglial activation and subsequent inflammation in the trigeminal nucleus caudalis (TNC) contribute to the central sensitization. The P2X7 receptor (P2X7R) is...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Jiang, Li, Zhang, Yixin, Jing, Feng, Long, Ting, Qin, Guangcheng, Zhang, Dunke, Chen, Lixue, Zhou, Jiying
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7786980/
https://ncbi.nlm.nih.gov/pubmed/33402188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-02056-0
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