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Neurovascular drug biotransformation machinery in focal human epilepsies: Brain CYP3A4 correlates with seizure frequency and antiepileptic drug therapy
Pharmacoresistance is a major clinical challenge for approximately 30% of patients with epilepsy. Previous studies indicate nuclear receptors (NRs), efflux transporters and cytochrome P450 enzymes (CYPs) control drug passage across the blood-brain barrier (BBB) in drug resistant epilepsy. Here we 1)...
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| Publicado no: | Mol Neurobiol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6854685/ https://ncbi.nlm.nih.gov/pubmed/31243719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-01673-y |
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