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Neurovascular drug biotransformation machinery in focal human epilepsies: Brain CYP3A4 correlates with seizure frequency and antiepileptic drug therapy
Pharmacoresistance is a major clinical challenge for approximately 30% of patients with epilepsy. Previous studies indicate nuclear receptors (NRs), efflux transporters and cytochrome P450 enzymes (CYPs) control drug passage across the blood-brain barrier (BBB) in drug resistant epilepsy. Here we 1)...
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| Publicat a: | Mol Neurobiol |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6854685/ https://ncbi.nlm.nih.gov/pubmed/31243719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-01673-y |
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