Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality

Cyclophosphamide (CTX) is a chemotherapeutic agent widely used to treat ovarian, breast, and hematological cancers as well as autoimmune disorders. Such chemotherapy is associated with reproductive failure and premature ovarian insufficiency. The mechanism by which CTX and/or its main metabolite, ac...

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Pubblicato in:Free Radic Biol Med
Autori principali: Jeelani, Roohi, Khan, Sana N., Shaeib, Faten, Kohan-Ghadr, Hamid-Reza, Aldhaheri, Sarah R., Najafi, Tohid, Thakur, Mili, Morris, Robert, Abu-Soud, Husam M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854673/
https://ncbi.nlm.nih.gov/pubmed/28499912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.05.006
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