Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality

Cyclophosphamide (CTX) is a chemotherapeutic agent widely used to treat ovarian, breast, and hematological cancers as well as autoimmune disorders. Such chemotherapy is associated with reproductive failure and premature ovarian insufficiency. The mechanism by which CTX and/or its main metabolite, ac...

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Veröffentlicht in:Free Radic Biol Med
Hauptverfasser: Jeelani, Roohi, Khan, Sana N., Shaeib, Faten, Kohan-Ghadr, Hamid-Reza, Aldhaheri, Sarah R., Najafi, Tohid, Thakur, Mili, Morris, Robert, Abu-Soud, Husam M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854673/
https://ncbi.nlm.nih.gov/pubmed/28499912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.05.006
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