mTOR pathway in human cardiac hypertrophy caused by LEOPARD syndrome: a different role compared with animal models?

BACKGROUND: Animal studies suggested that blocking the activation of the mammalian target of rapamycin (mTOR) pathway might be effective to treat cardiac hypertrophy in LEOPARD syndrome (LS) caused by PTPN11 mutations. RESULTS: In the present study, mTOR pathway activity was examined in human myocar...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Orphanet J Rare Dis
Prif Awduron: Cui, Hao, Song, Lei, Zhu, Changsheng, Zhang, Ce, Tang, Bing, Wang, Shengwei, Wu, Guixin, Zou, Yubao, Huang, Xiaohong, Hui, Rutai, Wang, Shuiyun, Wang, Jizheng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2019
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854668/
https://ncbi.nlm.nih.gov/pubmed/31722741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13023-019-1204-4
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg