Cannabinoid receptor 2-selective agonist JWH015 attenuates bone cancer pain through the amelioration of impaired autophagy flux induced by inflammatory mediators in the spinal cord

Bone cancer pain (BCP) is a severe complication of advanced bone cancer. Although cannabinoid receptor 2 (CB2) agonists may have an analgesic effect, the underlying mechanism remains unclear. CB2 serves a protective role in various pathological states through the activation of autophagy. Therefore,...

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Publicat a:Mol Med Rep
Autors principals: Mao, Yanting, Huang, Yulin, Zhang, Ying, Wang, Chenchen, Wu, Hao, Tian, Xinyu, Liu, Yue, Hou, Bailing, Liang, Ying, Rong, Hui, Gu, Xiaoping, Ma, Zhengliang
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2019
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854597/
https://ncbi.nlm.nih.gov/pubmed/31661120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2019.10772
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