Spinal cannabinoid receptor 2 activation reduces hypersensitivity associated with bone cancer pain and improves the integrity of the blood–spinal cord barrier

BACKGROUND: Disruption of the blood–spinal cord barrier (BSCB) can facilitate inflammation that results in pain hypersensitivity. Proinflammatory cytokines produced by activated microglia and astrocytes damage the BSCB. This study aims to explore whether the BSCB is damaged in the bone cancer pain (...

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Detalhes bibliográficos
Publicado no:Reg Anesth Pain Med
Main Authors: Wang, Chenchen, Xu, Ke, Wang, Yu, Mao, Yanting, Huang, Yulin, Liang, Ying, Liu, Yue, Hao, Jing, Gu, Xiaoping, Ma, Zhengliang, Sun, Yu'e
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7513263/
https://ncbi.nlm.nih.gov/pubmed/32796132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rapm-2019-101262
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