The E3 Ubiquitin Ligase TBK1 Mediates the Degradation of Multiple Picornavirus VP3 Proteins by Phosphorylation and Ubiquitination

TANK-binding kinase 1 (TBK1) is essential for interferon beta (IFN-β) production and innate antiviral immunity. However, other, additional functions of TBK1 have remained elusive. Here, we showed that TBK1 is an E3 ubiquitin ligase that undergoes self-ubiquitylation in vitro in the presence of the E...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Li, Dan, Yang, Wenping, Ren, Jingjing, Ru, Yi, Zhang, Keshan, Fu, Shaozu, Liu, Xiangtao, Zheng, Haixue
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854495/
https://ncbi.nlm.nih.gov/pubmed/31534043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01438-19
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