Comparative muscle irritation and pharmacokinetics of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in beagle dogs

Florfenicol (FF) is a novel animal-specific amidohydrin broad-spectrum antibiotic. However, its aqueous solubility is extremely poor, far below the effective dose required for veterinary clinic. Thus, FF is often used in large doses, which significantly limits its preparation and application. To ove...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Fan, Guoqing, Zhang, Li, Shen, Yun, Shu, Gang, Yuan, Zhixiang, Lin, Juchun, Zhang, Wei, Peng, Guangneng, Zhong, Zhijun, Yin, Lizi, Fu, Hualin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853948/
https://ncbi.nlm.nih.gov/pubmed/31723173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53304-0
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