Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers

Molecular determinants governing the evolution of tumor subclones toward phylogenetic branches or fixation remain unknown. Using sequencing data, we model the propagation and selection of clones expressing distinct categories of BRAF mutations to estimate their evolutionary trajectories. We show tha...

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Publicado en:Nat Commun
Main Authors: Gopal, Priyanka, Sarihan, Elif Irem, Chie, Eui Kyu, Kuzmishin, Gwendolyn, Doken, Semihcan, Pennell, Nathan A., Raymond, Daniel P., Murthy, Sudish C., Ahmad, Usman, Raja, Siva, Almeida, Francisco, Sethi, Sonali, Gildea, Thomas R., Peacock, Craig D., Adams, Drew J., Abazeed, Mohamed E.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853924/
https://ncbi.nlm.nih.gov/pubmed/31723142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13161-x
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