Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers

Molecular determinants governing the evolution of tumor subclones toward phylogenetic branches or fixation remain unknown. Using sequencing data, we model the propagation and selection of clones expressing distinct categories of BRAF mutations to estimate their evolutionary trajectories. We show tha...

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Vydáno v:Nat Commun
Hlavní autoři: Gopal, Priyanka, Sarihan, Elif Irem, Chie, Eui Kyu, Kuzmishin, Gwendolyn, Doken, Semihcan, Pennell, Nathan A., Raymond, Daniel P., Murthy, Sudish C., Ahmad, Usman, Raja, Siva, Almeida, Francisco, Sethi, Sonali, Gildea, Thomas R., Peacock, Craig D., Adams, Drew J., Abazeed, Mohamed E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853924/
https://ncbi.nlm.nih.gov/pubmed/31723142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13161-x
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