SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma

Whether SOX2 and ACTL6A/TP63 interact with the Hippo‐YAP1 pathway in esophageal squamous cell carcinoma (ESCC) remains unclear. Here, we reveal that SOX2, ACTL6A, and TP63 are co‐amplified and upregulated in ESCC samples. Multiple SOX2 binding peaks in the locus of WWC1, a Hippo‐YAP1 regulator, and...

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Dades bibliogràfiques
Publicat a:Cancer Med
Autors principals: Chai, Yuhang, Li, Qihang, Zhao, Hongying, Zhang, Zhiyu, Yu, Xiaodan, Pang, Lijuan, Liu, Zheng, Zhao, Jin, Wang, Lianghai, Li, Feng
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Cancer Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853808/
https://ncbi.nlm.nih.gov/pubmed/31560173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2569
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