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SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma
Whether SOX2 and ACTL6A/TP63 interact with the Hippo‐YAP1 pathway in esophageal squamous cell carcinoma (ESCC) remains unclear. Here, we reveal that SOX2, ACTL6A, and TP63 are co‐amplified and upregulated in ESCC samples. Multiple SOX2 binding peaks in the locus of WWC1, a Hippo‐YAP1 regulator, and...
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| Publicado no: | Cancer Med |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6853808/ https://ncbi.nlm.nih.gov/pubmed/31560173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2569 |
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