SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma

Whether SOX2 and ACTL6A/TP63 interact with the Hippo‐YAP1 pathway in esophageal squamous cell carcinoma (ESCC) remains unclear. Here, we reveal that SOX2, ACTL6A, and TP63 are co‐amplified and upregulated in ESCC samples. Multiple SOX2 binding peaks in the locus of WWC1, a Hippo‐YAP1 regulator, and...

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Udgivet i:Cancer Med
Main Authors: Chai, Yuhang, Li, Qihang, Zhao, Hongying, Zhang, Zhiyu, Yu, Xiaodan, Pang, Lijuan, Liu, Zheng, Zhao, Jin, Wang, Lianghai, Li, Feng
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853808/
https://ncbi.nlm.nih.gov/pubmed/31560173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2569
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