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Tackling tumor heterogeneity and phenotypic plasticity in cancer precision medicine: our experience and a literature review

The predominant cause of cancer mortality is metastasis. The major impediment to cancer cure is the intrinsic or acquired resistance to currently available therapies. Cancer is heterogeneous at the genetic, epigenetic, and metabolic levels. And, while a molecular-targeted drug may be pathway-precise...

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Detalhes bibliográficos
Publicado no:Cancer Metastasis Rev
Main Authors: Sheng, Shijie, Bernardo, M. Margarida, Dzinic, Sijana H., Chen, Kang, Heath, Elisabeth I., Sakr, Wael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853189/
https://ncbi.nlm.nih.gov/pubmed/30484007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10555-018-9767-4
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