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Model‐Informed Dosing of Venetoclax in Healthy Subjects: An Exposure−Response Analysis

Venetoclax is an approved drug for the treatment of some hematological malignancies. Venetoclax can cause reduction in B‐lymphocyte counts as an on‐target effect. The purpose of this analysis is to quantify the relationship between venetoclax exposure and B‐lymphocyte levels to inform dosing of vene...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Dave, Nimita, Gopalakrishnan, Sathej, Mensing, Sven, Salem, Ahmed Hamed
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853148/
https://ncbi.nlm.nih.gov/pubmed/31268229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12665
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