Analysis of DLL3 and ASCL1 in Surgically Resected Small Cell Lung Cancer (HOT1702)

BACKGROUND. Delta‐like protein 3 (DLL3) is a Notch ligand that has an important role in the tumorigenesis of small cell lung cancer (SCLC). Recently, rovalpituzumab tesirine (Rova‐T), a DLL3‐targeted antibody‐drug conjugate, has been developed for treating SCLC. DLL3 is a transcriptional target of t...

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Pubblicato in:Oncologist
Autori principali: Furuta, Megumi, Sakakibara‐Konishi, Jun, Kikuchi, Hajime, Yokouchi, Hiroshi, Nishihara, Hiroshi, Minemura, Hiroyuki, Harada, Masao, Yamazaki, Shigeo, Akie, Kenji, Fujita, Yuka, Takamura, Kei, Kojima, Tetsuya, Harada, Toshiyuki, Minami, Yoshinori, Watanabe, Naomi, Oizumi, Satoshi, Suzuki, Hiroyuki, Nishimura, Masaharu, Dosaka‐Akita, Hirotoshi, Isobe, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2019
Soggetti:
Lung Cancer
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853124/
https://ncbi.nlm.nih.gov/pubmed/31068386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2018-0676
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