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N-Glycosylation is required for secretion of the precursor to brain-derived neurotrophic factor (proBDNF) carrying sulfated LacdiNAc structures

Brain-derived neurotrophic factor (BDNF) is generated by proteolytic cleavage of a prodomain from the proBDNF precursor either intracellularly by furin-like proteases or extracellularly by plasmin or matrix metalloproteinases. ProBDNF carries a single N-glycosylation sequon (Asn-127) that remains vi...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Benicky, Julius, Sanda, Miloslav, Brnakova Kennedy, Zuzana, Goldman, Radoslav
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851326/
https://ncbi.nlm.nih.gov/pubmed/31558607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009989
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