Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein

The mammalian CLOCK:BMAL1 transcription factor complex and its coactivators CREB-binding protein (CBP)/p300 and mixed-lineage leukemia 1 (MLL1) critically regulate circadian transcription and chromatin modification. Circadian oscillations are regulated by interactions of BMAL1's C-terminal tran...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Garg, Archit, Orru, Roberto, Ye, Weixiang, Distler, Ute, Chojnacki, Jeremy E., Köhn, Maja, Tenzer, Stefan, Sönnichsen, Carsten, Wolf, Eva
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851309/
https://ncbi.nlm.nih.gov/pubmed/31515273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009845
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