Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands

Retinol dehydrogenases catalyze the rate-limiting step in the biosynthesis of retinoic acid, a bioactive lipid molecule that regulates the expression of hundreds of genes by binding to nuclear transcription factors, the retinoic acid receptors. Several enzymes exhibit retinol dehydrogenase activitie...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Wu, Lizhi, Belyaeva, Olga V., Adams, Mark K., Klyuyeva, Alla V., Lee, Seung-Ah, Goggans, Kelli R., Kesterson, Robert A., Popov, Kirill M., Kedishvili, Natalia Y.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851290/
https://ncbi.nlm.nih.gov/pubmed/31562240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010835
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