Phthalate-Induced Fetal Leydig Cell Dysfunction Mediates Male Reproductive Tract Anomalies

Male fetal Leydig cells in the testis secrete androgen and insulin-like 3, determining the sexual differentiation. The abnormal development of fetal Leydig cells could lead to the reduction of androgen and insulin-like 3, thus causing the male reproductive tract anomalies in male neonates, including...

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Pubblicato in:Front Pharmacol
Autori principali: Wang, Yiyan, Ni, Chaobo, Li, Xiaoheng, Lin, Zhenkun, Zhu, Qiqi, Li, Linxi, Ge, Ren-Shan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851233/
https://ncbi.nlm.nih.gov/pubmed/31780936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01309
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