Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line

The proximal tubule is a particularly important site for ageing-related kidney damage. Sirtuin 1 (SIRT1), an NAD(+) (nicotinamide adenine dinucleotide)-dependent deacetylase in the proximal tubule, may be involved in renal injury associated with ageing. However, the mechanisms of SIRT1 regulation re...

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Pubblicato in:Sci Rep
Autori principali: Yamaji, Takahiro, Yamashita, Akio, Wakui, Hiromichi, Azushima, Kengo, Uneda, Kazushi, Fujikawa, Yumiko, Haku, Sona, Kobayashi, Ryu, Ohki, Kohji, Haruhara, Kotaro, Kinguchi, Sho, Ishii, Takeo, Yamada, Takayuki, Urate, Shingo, Suzuki, Toru, Abe, Eriko, Tanaka, Shohei, Kamimura, Daisuke, Ishigami, Tomoaki, Toya, Yoshiyuki, Takahashi, Hidehisa, Tamura, Kouichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851135/
https://ncbi.nlm.nih.gov/pubmed/31719572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52566-y
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