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Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau
Scientific evidence suggests that α-synuclein and tau have prion-like properties and that prion-like spreading and seeding of misfolded protein aggregates constitutes a central mechanism for neurodegeneration. Heparan sulfate proteoglycans (HSPGs) in the plasma membrane support this process by attac...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6851098/ https://ncbi.nlm.nih.gov/pubmed/31719623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53038-z |
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