GATA4 mutations are a cause of neonatal and childhood-onset diabetes

The GATA family zinc finger transcription factors GATA4 and GATA6 are known to play important roles in the development of the pancreas. In mice both Gata4 and Gata6 are required for pancreatic development. In humans GATA6 haploinsufficiency can cause pancreatic agenesis and heart defects. Congenital...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Shaw-Smith, Charles, De Franco, Elisa, Lango Allen, Hana, Batlle, Marta, Flanagan, Sarah E., Borowiec, Maciej, Taplin, Craig E., van Alfen-van der Velden, Janiëlle, Cruz-Rojo, Jaime, Perez de Nanclares, Guiomar, Miedzybrodzka, Zosia, Deja, Grazyna, Wlodarska, Iwona, Mlynarski, Wojciech, Ferrer, Jorge, Hattersley, Andrew T., Ellard, Sian
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850908/
https://ncbi.nlm.nih.gov/pubmed/24696446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0061
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