GATA4 mutations are a cause of neonatal and childhood-onset diabetes

The GATA family zinc finger transcription factors GATA4 and GATA6 are known to play important roles in the development of the pancreas. In mice both Gata4 and Gata6 are required for pancreatic development. In humans GATA6 haploinsufficiency can cause pancreatic agenesis and heart defects. Congenital...

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Bibliografiske detaljer
Udgivet i:Diabetes
Main Authors: Shaw-Smith, Charles, De Franco, Elisa, Lango Allen, Hana, Batlle, Marta, Flanagan, Sarah E., Borowiec, Maciej, Taplin, Craig E., van Alfen-van der Velden, Janiëlle, Cruz-Rojo, Jaime, Perez de Nanclares, Guiomar, Miedzybrodzka, Zosia, Deja, Grazyna, Wlodarska, Iwona, Mlynarski, Wojciech, Ferrer, Jorge, Hattersley, Andrew T., Ellard, Sian
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6850908/
https://ncbi.nlm.nih.gov/pubmed/24696446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0061
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