HIF-mediated Suppression of DEPTOR Confers Resistance to mTOR Kinase Inhibition in Renal Cancer

Mechanistic target of rapamycin (mTOR) is a fundamental regulator of cell growth, proliferation, and metabolism. mTOR is activated in renal cancer and accelerates tumor progression. Here, we report that the mTOR inhibitor, DEP domain-containing mTOR-interacting protein (DEPTOR), is strikingly suppre...

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Gepubliceerd in:iScience
Hoofdauteurs: Doan, Hong, Parsons, Alexander, Devkumar, Shruthi, Selvarajah, Jogitha, Miralles, Francesc, Carroll, Veronica A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6849413/
https://ncbi.nlm.nih.gov/pubmed/31710966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.047
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