Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level

Average arterial oxyhemoglobin saturation during sleep (AvSpO(2)S) is a clinically relevant measure of physiological stress associated with sleep-disordered breathing, and this measure predicts incident cardiovascular disease and mortality. Using high-depth whole-genome sequencing data from the Nati...

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Veröffentlicht in:Am J Hum Genet
Hauptverfasser: Liang, Jingjing, Cade, Brian E., He, Karen Y., Wang, Heming, Lee, Jiwon, Sofer, Tamar, Williams, Stephanie, Li, Ruitong, Chen, Han, Gottlieb, Daniel J., Evans, Daniel S., Guo, Xiuqing, Gharib, Sina A., Hale, Lauren, Hillman, David R., Lutsey, Pamela L., Mukherjee, Sutapa, Ochs-Balcom, Heather M., Palmer, Lyle J., Rhodes, Jessica, Purcell, Shaun, Patel, Sanjay R., Saxena, Richa, Stone, Katie L., Tang, Weihong, Tranah, Gregory J., Boerwinkle, Eric, Lin, Xihong, Liu, Yongmei, Psaty, Bruce M., Vasan, Ramachandran S., Cho, Michael H., Manichaikul, Ani, Silverman, Edwin K., Barr, R. Graham, Rich, Stephen S., Rotter, Jerome I., Wilson, James G., Redline, Susan, Zhu, Xiaofeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6849112/
https://ncbi.nlm.nih.gov/pubmed/31668705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2019.10.002
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