Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model

OBJECTIVES: Our goal was to “reverse translate” the human response to surgical sepsis into the mouse by modifying a widely adopted murine intra-abdominal sepsis model to engender a phenotype that conforms to current sepsis definitions and follows the most recent expert recommendations for animal pre...

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Publicado no:Crit Care Med
Main Authors: Stortz, Julie A., Hollen, McKenzie K., Nacionales, Dina C., Horiguchi, Hiroyuki, Ungaro, Ricardo, Dirain, Marvin L., Wang, Zhongkai, Wu, Quran, Wu, Kevin K., Kumar, Ashok, Foster, Thomas C., Stewart, Brian D., Ross, Julia A., Segal, Marc, Bihorac, Azra, Brakenridge, Scott, Moore, Frederick A., Wohlgemuth, Stephanie E., Leeuwenburgh, Christiaan, Mohr, Alicia M., Moldawer, Lyle L., Efron, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848973/
https://ncbi.nlm.nih.gov/pubmed/31389840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000003926
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