Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40‐hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target

AIMS: THN102 is a novel combination of modafinil and low‐dose flecainide, targeting glial connexin activity to modulate modafinil effects. We investigated THN102 efficacy compared to modafinil and to placebo on vigilance and cognitive function during 40‐hour total sleep deprivation (TSD). METHODS: T...

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Publicat a:Br J Clin Pharmacol
Autors principals: Sauvet, Fabien, Erblang, Mégane, Gomez‐Merino, Danielle, Rabat, Arnaud, Guillard, Mathias, Dubourdieu, Dominique, Lefloch, Hervé, Drogou, Catherine, Van Beers, Pascal, Bougard, Clément, Bourrrilhon, Cyprien, Arnal, Pierrick, Rein, Werner, Mouthon, Franck, Brunner‐Ferber, Francoise, Leger, Damien, Dauvilliers, Yves, Chennaoui, Mounir, Charvériat, Mathieu
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848897/
https://ncbi.nlm.nih.gov/pubmed/31419329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14098
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