Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40‐hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target

AIMS: THN102 is a novel combination of modafinil and low‐dose flecainide, targeting glial connexin activity to modulate modafinil effects. We investigated THN102 efficacy compared to modafinil and to placebo on vigilance and cognitive function during 40‐hour total sleep deprivation (TSD). METHODS: T...

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Publicado no:Br J Clin Pharmacol
Main Authors: Sauvet, Fabien, Erblang, Mégane, Gomez‐Merino, Danielle, Rabat, Arnaud, Guillard, Mathias, Dubourdieu, Dominique, Lefloch, Hervé, Drogou, Catherine, Van Beers, Pascal, Bougard, Clément, Bourrrilhon, Cyprien, Arnal, Pierrick, Rein, Werner, Mouthon, Franck, Brunner‐Ferber, Francoise, Leger, Damien, Dauvilliers, Yves, Chennaoui, Mounir, Charvériat, Mathieu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848897/
https://ncbi.nlm.nih.gov/pubmed/31419329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14098
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